منابع مشابه
Potentiating Endogenous Bombesin-like Peptides
Bombesin-like peptides (BLPs) are mitogens for bronchial epithelial cells and small cell lung carcinomas, and increase fetal lung growth and maturation in utero and in organ cultures. BLPs are hydrolyzed by the enzyme CD10/neutral endopeptidase 24.11 (CD10/NEP) which is expressed in bronchial epithelium and functions to inhibit BLP-mediated growth of small cell lung carcinomas. To determine whe...
متن کاملDevelopment and function of bombesin-like peptides and their receptors.
Amphibian bombesin and its related peptides consist a family of neuropeptides in many vertebrate species. Bombesin and two major bombesin-like peptide in mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various physiological effects. These include inhibition of feeding, smooth muscle contraction, exocrine and endocrine secretions, thermoregulation, bloo...
متن کاملBombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.
RATIONALE The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, is paradoxically rising despite medical advances. We demonstrated elevated bombesin-like peptide levels in infants that later developed BPD. In the 140-day hyperoxic baboon model of BPD, anti-bombesin antibody 2A11 abrogated lung injury. OBJECTIVES To test the hypothesis that bombesin-like peptide...
متن کاملStress and eating: a dual role for bombesin-like peptides
The current obesity "epidemic" in the developed world is a major health concern; over half of adult Canadians are now classified as overweight or obese. Although the reasons for high obesity rates remain unknown, an important factor appears to be the role stressors play in overconsumption of food and weight gain. In this context, increased stressor exposure and/or perceived stress may influence...
متن کاملEvaluation of a series of new 99mTc-labeled bombesin-like peptides for early cancer detection.
Bombesin (BN) is a peptide exhibiting a high affinity for the gastrin-releasing peptide (GRP) receptor, which is overexpressed by a variety of tumors, including breast or prostate cancer. The aim of the present study was the investigation of the complexes formed between a series of BN-like peptides and the nuclides (185/187)Re and 99mTc. The (185/187)Re complexes were formed via the precursor R...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1975
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1975.tb07631.x